Amyloidosis associated with cyclic neutropenia in the dog.
نویسنده
چکیده
منابع مشابه
A case of generalized amyloidosis associated with cyclic neutropenia.
A case of generalized amyloidosis associated with cyclic neutropenia is presented. A 24-yr-old female with cyclic neutropenia died from intestinal obstruction caused by necrosis and perforation of the small intestine. Post-mortem examination revealed generalized amyloidosis involving almost all organs. Amyloid deposits were prominent, especially in the alimentary tract, kidneys, spleen, and sma...
متن کاملCanine cyclic neutropenia: Erythropoietin and platelet cycles after bone marrow transplantation.
The marrow of a dog affected with cyclic neutropenia (CN) was transplanted into an unaffected supralethally irradiated litermate. Prompt engraftment occurred, and cyclic rises and falls in numbers of platelets, reticulocytes, and granulocytes were noted in the recipient soon after engraftment. Prior to transplantation and under hypoxic conditions, the donor had serum erythropoietin (ESF) peak l...
متن کاملOral cyclic melphalan and dexamethasone for patients with AL amyloidosis.
PURPOSE Aggressive treatment of amyloid light chain (AL) amyloidosis with high-dose intravenous melphalan followed by autologous stem cell transplantation (HDM/SCT) is effective in inducing hematologic remission and clinical improvement. However, only selected patients with AL amyloidosis are eligible for HDM/SCT because of amyloid-associated organ dysfunction. PATIENTS AND METHODS We report ...
متن کاملHuman cyclic neutropenia transferred by allogeneic bone marrow grafting.
Human cyclic neutropenia shows many features in common with the animal model of cyclic neutropenia in grey collie dogs. Until now, however, evidence was lacking that cyclic neutropenia in man as in the dog is caused by a defect in a transplantable hematopoietic stem cell. A patient is presented who, while undergoing bone marrow transplantation as treatment for acute lymphoblastic leukemia in re...
متن کاملLithium therapy of canine cyclic hematopoiesis.
Treatment of cyclic hematopoiesis in the grey collie dog with lithium carbonate eliminated the recurrent neutropenia and normalized the other blood cell counts. These findings suggest that human cyclic hematopoiesis may be successfully treated with lithium. The effects of lithium on the monocytes, platelets, and reticulocytes, as well as the neutrophils, suggest that lithium operates on basic r...
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ورودعنوان ژورنال:
- Blood
دوره 31 1 شماره
صفحات -
تاریخ انتشار 1968